The test dimensions for those analyses wasn’t place a beneficial priori, and just the fresh new offered data away from each data were utilized.
Patient characteristics and you can variation with age
Desk step 1 refers to the new standard qualities of your own 6442 clients assessed (Extra document step one: Table S1 provides such studies each study). Overall, a bit lower than you to definitely-half of the newest people had been ladies, even though this ratio improved with increasing ages. The fresh mean (SD) period of people try 63.2 (10.9) age, and their anthropometric strategies revealed that 46.5% had been for the list of being obese [complete indicate (SD) BMI: 29.step 3 (5.2) kg/yards dos ], mostly of one’s central particular (imply waist circumference, all: 101.8 cm; women: 99.5 cm, men: 103.seven cm). The latest imply (SD) time of T2D is actually 7.4 (six.7) decades, and more than 90% of customers was searching dental antidiabetes medications; the rest are finding lives transform advice simply. Imply FBG and you may, including, suggest HbA1c was indeed over traditional low-personalized recommended plans (imply FBG: nine.0 mmol/L; indicate HbA1c: eight.4%). Except that HDL-C, SBP, and you can DBP, imply thinking of the kept traditional aerobic risk activities (LDL-C and you may triglycerides) was indeed above the demanded thresholds. These types of thresholds are summarized in the Profile step one.
Vintage cardio chance issues and other diligent services stratified of the ages, Bmi, and you may HbA1c ranges. Thinking was means and you will 95% trust menstruation, computed in the conveyed strata of one’s established variables (decades, Body mass index, and HbA1c). The fresh vertical dotted contours in some maps depict address philosophy necessary by the Western All forms of diabetes Organization . Celebrities = age; Triangles = BMI; Circles = HbA1c. Abbreviations: Bmi, body mass index; DBP, diastolic blood circulation pressure; FBG, smooth blood sugar levels; HbA1c, glycosylated hemoglobin; HDL, high-density lipoprotein; LDL, low-occurrence lipoprotein; SBP, systolic hypertension; T2D, diabetes.
A greater proportion of men than women was in the overweight range (BMI 25 to <30 kg/m 2 ), while women were more frequently in the obese range (BMI ?30 kg/m 2 ), in particular BMI 35 to <40 kg/m 2 . Smoking was more common among men than women (Table 1).There was an inverse relationship between age group and BMI, HbA1c, triglyceride, and DBP levels (Figure 1 stars: charts 2, 5, 8, and 10, respectively). Conversely, as age increased, the duration of T2D also increased, as did HDL-C and SBP levels (Figure 1 stars: charts 4, 6, and 9, respectively).
Body mass index and you will cardiovascular exposure things
Triglyceride, SBP, and DBP levels were directly correlated with BMI strata 
(Figure 1 triangles: charts 8–10, respectively). Conversely, as BMI increased, HDL-C levels decreased (Figure 1 triangles: chart 6); LDL-C levels did not show strong trends with BMI in either direction (Figure 1 triangles: chart 7). The generalized logit analysis confirmed positive associations between increasing BMI strata and SBP, DBP, and triglyceride levels as significant (P < .05 for all). It also indicated an inverse association between increasing BMI strata and HDL-C levels (P < .001) and a weaker inverse association between increasing BMI strata and LDL-C levels (P < .05).
There was an inverse relationship between BMI strata and both age and duration of T2D (Figure 1 triangles: charts 1 and 4, respectively). The generalized logit analysis confirmed these associations were significant (P < .001). HbA1c did not appear to be correlated with BMI strata (Figure 1 triangles: chart 5). 001).
HbA1c and you can cardiovascular exposure things
Increased values for the cardiovascular risk factors LDL-C, triglycerides, SBP, and DBP, and decreased levels of HDL-C were related to higher HbA1c strata (Figure 1 circles: charts 7–10 and 6, respectively). In the generalized logit analysis, lower HDL-C (P < .001) and higher TC levels (P < .001) were associated with higher HbA1c strata. BMI and waist circumference did not show an association with HbA1c (Figure 1 circles: charts 2 and 3, respectively).